Article
Aflatoxin B1 modulates the expression of phenotypic markers and cytokines by splenic lymphocytes of male F344 rats.
Journal of applied toxicology : JAT - 1 Mar 2014
Qian Guoqing, Tang Lili, Guo Xia, Wang Franklin, Massey Michael E, Su Jianjia, Guo Tai L, Williams Jonathan H, Phillips Timothy D, Wang Jia-Sheng
Abstract excerpt
Aflatoxin B1 (AFB1) is immunotoxic to animals and a suspected immunosuppressant in humans. In this study, we investigated the effects of AFB1 on splenic lymphocyte phenotypes and the inflammatory cytokine expression in male F344 rats. Exposure of animals to AFB1 [5-75 µg kg(-1) body weight (BW)] for 1 week showed dose-dependent decreases in the percentage of splenic CD8(+) T cells and CD3(-) CD8a(+) NK cells. A...
Topics
- Administration, Oral
- Aflatoxin B1
- Animals
- B-Lymphocytes
- Cytokines
- Dose-Response Relationship, Drug
- Environmental Pollutants
- Flow Cytometry
- Killer Cells, Natural
- Lymphocytes
- Male
- Phenotype
- Rats