CIITA-induced MHC class II expression in mammary adenocarcinoma leads to a Th1 polarization of the tumor microenvironment, tumor rejection, and specific antitumor memory.

doi:10.1158/1078-0432.CCR-06-0165

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CIITA-induced MHC class II expression in mammary adenocarcinoma leads to a Th1 polarization of the tumor microenvironment, tumor rejection, and specific antitumor memory.

Clinical cancer research : an official journal of the American Association for Cancer Research - 1 Jun 2006

Mortara Lorenzo, Castellani Patrizia, Meazza Raffaella, Tosi Giovanna, De Lerma Barbaro Andrea, Procopio Francesco A, Comes Alberto, Zardi Luciano, Ferrini Silvano, Accolla Roberto S

Abstract excerpt

PURPOSE: We have shown previously that the MHC class II-negative murine TS/A adenocarcinoma is rejected in vivo if induced to express MHC class II molecules by transfection of the MHC class II transactivator CIITA. In this study, we explored the immunologic basis of tumor rejection and the correlation between histopathology of tumor tissue and immune rejection. EXPERIMENTAL DESIGN: Stable TS/A-CIITA transfectants...

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CIITA-induced MHC class II expression in mammary adenocarcinoma leads to a Th1 polarization of the tumor microenvironment, tumor rejection, and specific antitumor memory.

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