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Article

Autocrine GABA signaling distinctively regulates phenotypic activation of mouse pulmonary macrophages.

Cellular immunology - 1 Oct 2018

Januzi Luan, Poirier Jacob W, Maksoud Matthew J E, Xiang Yun-Yan, Veldhuizen Rudolf A W, Gill Sean E, Cregan Sean P, Zhang Haibo, Dekaban Gregory A, Lu Wei-Yang

Abstract excerpt

In response to micro-environmental cues such as microbial infections or T-helper 1 and 2 (TH1 and TH2) cytokines, macrophages (Mϕs) develop into M1- or M2-like phenotypes. Phenotypic polarization/activation of Mϕs are also essentially regulated by autocrine signals. Type-A γ-aminobutyric acid receptor (GABAAR)-mediated autocrine signaling is critical for phenotypic differentiation and transformation of various...

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PMID: 30017085
DOI: 10.1016/j.cellimm.2018.07.001

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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