Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Impact of bacteria on the phenotype, functions, and therapeutic activities of invariant NKT cells in mice.

The Journal of clinical investigation - 1 Jun 2008

Kim Sungjune, Lalani Saif, Parekh Vrajesh V, Vincent Tiffaney L, Wu Lan, Van Kaer Luc

Abstract excerpt

Invariant NKT (iNKT) cells are innate-like lymphocytes that recognize glycolipid antigens in the context of the MHC class I-like antigen-presenting molecule CD1d. In vivo activation of mouse iNKT cells with the glycolipid alpha-galactosylceramide (alpha-GalCer) results in the acquisition of a hyporesponsive (anergic) phenotype by these cells. Because iNKT cells can become activated in the context of infectious...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Flagellin
Share to Interleukin-12

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Interleukin-4

Share to Killer Cells, Natural

Share to Kinetics

Share to Lipopolysaccharides

Share to Lymphocytes

Share to Models, Biological

Source

Open in PubMed Open full text

Identifiers

PMID: 18451996
DOI: 10.1172/JCI33071
PMCID: PMC2350429

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Impact of bacteria on the phenotype, functions, and therapeutic activities of invariant NKT cells in mice.PMID 18451996Read ↗

Intestinal microbes affect phenotypes and functions of invariant natural killer T cells in mice.Semantic proximity Read ↗

PD-1/PD-L blockade prevents anergy induction and enhances the anti-tumor activities of glycolipid-activated invariant NKT cells.Semantic proximity Read ↗

Bacterial infection alters the kinetics and function of iNKT cell responses.Semantic proximity Read ↗

Rapid activation and hepatic recruitment of innate-like regulatory B cells after invariant NKT cell stimulation in mice.Semantic proximity Read ↗

Characterization and Functional Analysis of Mouse Semi-invariant Natural T Cells.Semantic proximity Read ↗

Repeated alpha-galactosylceramide administration results in expansion of NK T cells and alleviates inflammatory dermatitis in MRL-lpr/lpr mice.Semantic proximity Read ↗

CD1d-restricted glycolipid antigens: presentation principles, recognition logic and functional consequences.Semantic proximity Read ↗

Alpha-galactosylceramide-induced liver injury in mice is mediated by TNF-alpha but independent of Kupffer cells.Semantic proximity Read ↗

Development of spontaneous anergy in invariant natural killer T cells in a mouse model of dyslipidemia.Semantic proximity Read ↗

Activation of invariant NK T cells protects against experimental rheumatoid arthritis by an IL-10-dependent pathway.Semantic proximity Read ↗

A Subset of CD8αβ+ Invariant NKT Cells in a Humanized Mouse Model.Semantic proximity Read ↗

Activation-induced NKT cell hyporesponsiveness protects from alpha-galactosylceramide hepatitis and is independent of active transregulatory factors.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.