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Article

SHP2 positively regulates TGFβ1-induced epithelial-mesenchymal transition modulated by its novel interacting protein Hook1.

The Journal of biological chemistry - 5 Dec 2014

Li Shuomin, Wang Linrun, Zhao Qingwei, Liu Yu, He Lingjuan, Xu Qinqin, Sun Xu, Teng Li, Cheng Hongqiang, Ke Yuehai

Abstract excerpt

The epithelial-mesenchymal transition (EMT) is an essential process for embryogenesis. It also plays a critical role in the initiation of tumor metastasis. Src homology 2 (SH2)-domain containing protein-tyrosine phosphatase-2 (SHP2) is a ubiquitously expressed protein-tyrosine phosphatase and is mutated in many tumors. However, its functional role in tumor metastasis remains largely unknown. We found that...

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Identifiers

PMID: 25331952
DOI: 10.1074/jbc.M113.546077
PMCID: PMC4256348

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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