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Article

Single-cell transcriptomics reveals opposing roles of Shp2 in Myc-driven liver tumor cells and microenvironment.

Cell reports - 9 Nov 2021

Chen Wendy S, Liang Yan, Zong Min, Liu Jacey J, Kaneko Kota, Hanley Kaisa L, Zhang Kun, Feng Gen-Sheng

Abstract excerpt

The mechanisms of Myc-driven liver tumorigenesis are inadequately understood. Herein we show that Myc-driven hepatocellular carcinoma (HCC) is dramatically aggravated in mice with hepatocyte-specific Ptpn11/Shp2 deletion. However, Myc-induced tumors develop selectively from the rare Shp2-positive hepatocytes in Shp2-deficent liver, and Myc-driven oncogenesis depends on an intact Ras-Erk signaling promoted by Shp2...

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Identifiers

PMID: 34758313
DOI: 10.1016/j.celrep.2021.109974
PMCID: PMC8656042

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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