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Article

p53-Pirh2 Complex Promotes Twist1 Degradation and Inhibits EMT.

Molecular cancer research : MCR - 1 Jan 2019

Yang-Hartwich Yang, Tedja Roslyn, Roberts Cai M, Goodner-Bingham Jamie, Cardenas Carlos, Gurea Marta, Sumi Natalia J, Alvero Ayesha B, Glackin Carlotta A, Mor Gil

Abstract excerpt

Epithelial-mesenchymal transition (EMT) is a critical process involved in cancer metastasis and chemoresistance. Twist1 is a key EMT-inducing transcription factor, which is upregulated in multiple types of cancers and has been shown to promote tumor cell invasiveness and support tumor progression. Conversely, p53 is a tumor suppressor gene that is frequently mutated in cancers. This study demonstrates the ability...

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Source

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Identifiers

PMID: 30131448
DOI: 10.1158/1541-7786.MCR-18-0238
PMCID: PMC6800184

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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