Article
Inhibition of SHP2 leads to mesenchymal to epithelial transition in breast cancer cells.
Cell death and differentiation - 1 Jun 2008
Zhou X-D, Agazie Y M
Abstract excerpt
The Src homology phosphotyrosyl phosphatase 2 (SHP2) is an essential transducer of mitogenic and cell survival signaling in the epidermal growth factor receptor (EGFR) signaling pathway. However, the role of SHP2 in aberrant EGFR and human EGFR2 (HER2) signaling and cancer, particularly in breast cancer, has not been investigated. Here, we report that SHP2 is required for mitogenic and cell survival signaling and...
Topics
- Breast Neoplasms
- Cell Line, Tumor
- Cell Movement
- Cell Transformation, Neoplastic
- Epithelial Cells
- Extracellular Signal-Regulated MAP Kinases
- Female
- Humans
- Mesoderm
- Phenotype
- Protein Tyrosine Phosphatase, Non-Receptor Type 11