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Article

Proteomic signatures associated with p53 mutational status in lung adenocarcinoma.

Proteomics - 1 Dec 2014

Taguchi Ayumu, Delgado Oliver, Celiktaş Müge, Katayama Hiroyuki, Wang Hong, Gazdar Adi F, Hanash Samir M

Abstract excerpt

p53 is commonly mutated in lung adenocarcinoma. Mutant p53 loses wild-type function and some missense mutations further acquire oncogenic functions, while p53 wild-type may also induce pro-survival signaling. Therefore identification of signatures based on p53 mutational status has relevance to our understanding of p53 signaling pathways in cancer and identification of new therapeutic targets. To this end, we...

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Source

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Identifiers

PMID: 25331784
DOI: 10.1002/pmic.201400378
PMCID: PMC4403731

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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