Article
The Role of Proteomics and Phosphoproteomics in the Discovery of Therapeutic Targets and Biomarkers in Acquired EGFR-TKI-Resistant Non-Small Cell Lung Cancer.
International journal of molecular sciences - 2 Mar 2023
Moonmuang Sutpirat, Tantraworasin Apichat, Orrapin Santhasiri, Udomruk Sasimol, Chewaskulyong Busyamas, Pruksakorn Dumnoensun, Chaiyawat Parunya
Abstract excerpt
The discovery of potent EGFR-tyrosine kinase inhibitors (EGFR-TKIs) has revolutionized the treatment of EGFR-mutated lung cancer. Despite the fact that EGFR-TKIs have yielded several significant benefits for lung cancer patients, the emergence of resistance to EGFR-TKIs has been a substantial impediment to improving treatment outcomes. Understanding the molecular mechanisms underlying resistance is crucial for...
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