Article
Significance of TP53 Mutation in Cellular Process and Disease Progression in Lung Adenocarcinoma.
Genetic testing and molecular biomarkers - 1 May 2021
Hou Yongbo, Tan Sheng, Wang Guoxiang
Abstract excerpt
Introduction: TP53 (tumor protein p53) is one of the most commonly mutanted genes in lung adenocarcinoma (LUAD). Materials and Methods: In this study, we used data from The Cancer Genome Atlas (TCGA) to evaluate the importance of TP53 mutations in cellular processes, disease progression, the prognosis in LUAD, and to identify critical hub genes and pathways associated with oncogenesis. Results: Analysis of the...
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