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Article

p53 mutants G245S and R337H associated with the Li-Fraumeni syndrome regulate distinct metabolic pathways.

Biochimie - 1 Jul 2022

Meneghetti Bruna Valandro, Wilson Richard, Dias Camila Kehl, Cadore Nathan Araujo, Klamt Fábio, Zaha Arnaldo, Ferreira Henrique Bunselmeyer, Monteiro Karina Mariante

Abstract excerpt

Li-Fraumeni and Li-Fraumeni-like syndromes (LFS/LFL) are hereditary cancer predisposition disorders associated with germline mutations in the TP53 tumor suppressor gene. Here, we stably expressed LFS/LFL-associated p53 mutants R337H and G245S in p53-null H1299 cells to study their cellular and molecular effects. Mutant proteins showed distinct oligomerization states and opposing effects on cell proliferation and...

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Identifiers

PMID: 35367578
DOI: 10.1016/j.biochi.2022.03.003

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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