Article
Comparisons of tyrosine phosphorylated proteins in cells expressing lung cancer-specific alleles of EGFR and KRAS.
Proceedings of the National Academy of Sciences of the United States of America - 16 Sept 2008
Guha Udayan, Chaerkady Raghothama, Marimuthu Arivusudar, Patterson A Scott, Kashyap Manoj K, Harsha H C, Sato Mitsuo, Bader Joel S, Lash Alex E, Minna John D, Pandey Akhilesh, Varmus Harold E
Abstract excerpt
We have used unbiased phosphoproteomic approaches, based on quantitative mass spectrometry using stable isotope labeling with amino acids in cell culture (SILAC), to identify tyrosine phosphorylated proteins in isogenic human bronchial epithelial cells (HBECs) and human lung adenocarcinoma cell lines, expressing either of the two mutant alleles of EGFR (L858R and Del E746-A750), or a mutant KRAS allele, which are...
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