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Article

Sudden telomere lengthening triggers a Rad53-dependent checkpoint in Saccharomyces cerevisiae.

Molecular biology of the cell - 1 Aug 2003

Viscardi Valeria, Baroni Enrico, Romano Michele, Lucchini Giovanna, Longhese Maria Pia

Abstract excerpt

Telomeres are specialized functional complexes that ensure chromosome stability by protecting chromosome ends from fusions and degradation and avoiding chromosomal termini from being sensed as DNA breaks. Budding yeast Tel1 is required both for telomere metabolism and for a Rad53-dependent checkpoint responding to unprocessed double-strand breaks. We show that overexpression of a GAL1-TEL1 fusion causes transient...

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Cell Cycle
Checkpoint Kinase 2
Endonucleases
Genes, cdc
Intracellular Signaling Peptides and Proteins

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Telomere-Binding Proteins

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PMID: 12925751
DOI: 10.1091/mbc.e02-11-0719
PMCID: PMC181555

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Sudden telomere lengthening triggers a Rad53-dependent checkpoint in Saccharomyces cerevisiae.PMID 12925751Read ↗

Rif1 and Exo1 regulate the genomic instability following telomere losses.Semantic proximity Read ↗

Est1 protects telomeres and inhibits subtelomeric y'-element recombination.Semantic proximity Read ↗

SGS1 is required for telomere elongation in the absence of telomerase.Semantic proximity Read ↗

Est1 and Cdc13 as comediators of telomerase access.Semantic proximity Read ↗

Kinase-independent functions of TEL1 in telomere maintenance.Semantic proximity Read ↗

A yeast telomerase complex containing the Est1 recruitment protein is assembled early in the cell cycle.Semantic proximity Read ↗

The Saccharomyces telomere-binding protein Cdc13p interacts with both the catalytic subunit of DNA polymerase alpha and the telomerase-associated est1 protein.Semantic proximity Read ↗

Delivery of yeast telomerase to a DNA break depends on the recruitment functions of Cdc13 and Est1.Semantic proximity Read ↗

Senescence mutants of Saccharomyces cerevisiae with a defect in telomere replication identify three additional EST genes.Semantic proximity Read ↗

Rif1 supports the function of the CST complex in yeast telomere capping.Semantic proximity Read ↗

The Est1 subunit of yeast telomerase binds the Tlc1 telomerase RNA.Semantic proximity Read ↗

Recruitment of Rad51 and Rad52 to short telomeres triggers a Mec1-mediated hypersensitivity to double-stranded DNA breaks in senescent budding yeast.Semantic proximity Read ↗

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