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Article

Gene-based rare allele analysis identified a risk gene of Alzheimer's disease.

PloS one - 1 Jan 2014

Kim Jong Hun, Song Pamela, Lim Hyunsun, Lee Jae-Hyung, Lee Jun Hong, Park Sun Ah

Abstract excerpt

Alzheimer's disease (AD) has a strong propensity to run in families. However, the known risk genes excluding APOE are not clinically useful. In various complex diseases, gene studies have targeted rare alleles for unsolved heritability. Our study aims to elucidate previously unknown risk genes for AD by targeting rare alleles. We used data from five publicly available genetic studies from the Alzheimer's Disease...

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Identifiers

PMID: 25329708
DOI: 10.1371/journal.pone.0107983
PMCID: PMC4203677

Genes

APOE
TREM2

Provenance

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