Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Application of the STAAR framework in detecting rare variant associations with Alzheimer disease and related dementias: Insights and implications.

HGG advances - 9 Apr 2026

Wang Dongyu, Abbruzzese Sabrina, Heard-Costa Nancy, Rampersaud Andy, Martin Eden, Naj Adam, Akgun Bilcag, Kunkle Brian, Seshadri Sudha, Peloso Gina, DeStefano Anita L, Li Zilin, Li Xihao, Choi Seung Hoan

Abstract excerpt

Rare genetic variation is considered a potential source of heritability in individuals with sporadic Alzheimer disease and related dementias (ADRD). The Variant-set test for association using annotation information (STAAR) framework leverages multiple functional annotations of genetic variants and combines association statistics from multiple variant aggregation-based methods, including burden, sequence kernel...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Alzheimer Disease
Share to Dementia

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to CARD11 gene

Share to Genetic Predisposition to Disease

Share to Genetic Variation

Share to Genome-Wide Association Study

Share to Whole Genome Sequencing

Source

Open in PubMed Open full text

Identifiers

PMID: 41560352
DOI: 10.1016/j.xhgg.2026.100574
PMCID: PMC12934298

Genes

CARD11
PLXNB2
TBX19
ZNF200

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 3 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Application of the STAAR framework in detecting rare variant associations with Alzheimer disease and related dementias: Insights and implications.PMID 41560352Read ↗

Population-scale burden analysis of rare damaging coding variants identifies novel risk genes for Alzheimer’s disease and related dementias and Parkinson’s disease and related disordersSemantic proximity Read ↗

The impact of rare genetic variants on Alzheimer disease.Semantic proximity Read ↗

Rare coding variants from ADSP R5 whole-genome sequencing implicate novel genes in Alzheimer’s diseaseSemantic proximity Read ↗

An empirical Bayes framework for burden and dispersion association tests helps prioritize rare variants associated with Alzheimer’s diseaseSemantic proximity Read ↗

Comprehensive adjudication identifies 111 high-confidence loci for Alzheimer's disease and related dementiasSemantic proximity Read ↗

Whole Exome Sequencing in 20,197 Persons for Rare Variants in Alzheimer DiseaseSemantic proximity Read ↗

Beyond guilty by association at scale: searching for causal variants on the basis of genome-wide summary statisticsSemantic proximity Read ↗

Gene-based rare allele analysis identified a risk gene of Alzheimer's disease.Semantic proximity Read ↗

Whole-genome sequencing reveals new Alzheimer’s disease-associated rare variants in loci related to synaptic function and neuronal developmentSemantic proximity Read ↗

Leveraging functional annotations to map rare variants associated with Alzheimer disease with gruyere.Semantic proximity Read ↗

Leveraging functional annotations to map rare variants associated with Alzheimer’s disease with gruyereSemantic proximity Read ↗

Whole-genome sequencing reveals new Alzheimer's disease-associated rare variants in loci related to synaptic function and neuronal development.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.