Article
Challenge accepted: uncovering the role of rare genetic variants in Alzheimer's disease.
Molecular neurodegeneration - 9 Jan 2022
Khani Marzieh, Gibbons Elizabeth, Bras Jose, Guerreiro Rita
Abstract excerpt
The search for rare variants in Alzheimer's disease (AD) is usually deemed a high-risk - high-reward situation. The challenges associated with this endeavor are real. Still, the application of genome-wide technologies to large numbers of cases and controls or to small, well-characterized families has started to be fruitful.Rare variants associated with AD have been shown to increase risk or cause disease, but...
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