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Article

The impact of rare genetic variants on Alzheimer disease.

Nature reviews. Neurology - 1 Mar 2025

De Deyn Lara, Sleegers Kristel

Abstract excerpt

Alzheimer disease (AD) is a progressive neurodegenerative disease with a strong genetic component. Although autosomal dominant mutations and common risk variants in AD risk have been extensively studied, the genetic underpinning of polygenic AD remains incompletely understood. Rare variants could elucidate part of the missing heritability in AD. Rare variant research gained momentum with the discovery of a rare...

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Identifiers

PMID: 39905212
DOI: 10.1038/s41582-025-01062-1

Genes

ABCA7
SORL1
TREM2

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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