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Article

Genetic variations underlying Alzheimer's disease: evidence from genome-wide association studies and beyond.

The Lancet. Neurology - 1 Jul 2016

Cuyvers Elise, Sleegers Kristel

Abstract excerpt

With the advent of genome-wide association studies (GWAS) and next-generation sequencing, more than 20 risk loci that affect Alzheimer's disease have been identified. These loci are estimated to explain about 28% of the heritability of liability, 30% of familial risk, and over 50% of sibling recurrence risk of developing Alzheimer's disease. These estimates are high in comparison with those for other complex...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 27302364
DOI: 10.1016/S1474-4422(16)00127-7

Genes

APOE
TREM2

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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