Article
The challenges of genome-wide interaction studies: lessons to learn from the analysis of HDL blood levels.
PloS one - 1 Jan 2014
van Leeuwen Elisabeth M, Smouter Françoise A S, Kam-Thong Tony, Karbalai Nazanin, Smith Albert V, Harris Tamara B, Launer Lenore J, Sitlani Colleen M, Li Guo, Brody Jennifer A, Bis Joshua C, White Charles C, Jaiswal Alok, Oostra Ben A, Hofman Albert, Rivadeneira Fernando, Uitterlinden Andre G, Boerwinkle Eric, Ballantyne Christie M, Gudnason Vilmundur, Psaty Bruce M, Cupples L Adrienne, Järvelin Marjo-Riitta, Ripatti Samuli, Isaacs Aaron, Müller-Myhsok Bertram, Karssen Lennart C, van Duijn Cornelia M
Abstract excerpt
Genome-wide association studies (GWAS) have revealed 74 single nucleotide polymorphisms (SNPs) associated with high-density lipoprotein cholesterol (HDL) blood levels. This study is, to our knowledge, the first genome-wide interaction study (GWIS) to identify SNP×SNP interactions associated with HDL levels. We performed a GWIS in the Rotterdam Study (RS) cohort I (RS-I) using the GLIDE tool which leverages the...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.