Article
Evidence of differential allelic effects between adolescents and adults for plasma high-density lipoprotein.
PloS one - 1 Jan 2012
Middelberg Rita P S, Heath Andrew C, Madden Pamela A F, Montgomery Grant W, Martin Nicholas G, Whitfield John B
Abstract excerpt
A recent meta-analysis of genome-wide association (GWA) studies identified 95 loci that influence lipid traits in the adult population and found that collectively these explained about 25-30% of heritability for each trait. Little is known about how these loci affect lipid levels in early life, but there is evidence that genetic effects on HDL- and LDL-cholesterol (HDL-C, LDL-C) and triglycerides vary with age....
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