Article
Refinement of a Published Gene-Physical Activity Interaction Impacting HDL-Cholesterol: Role of Sex and Lipoprotein Subfractions.
Genetic epidemiology - 1 Jan 2025
Westerman Kenneth E, Kilpeläinen Tuomas O, Sevilla-Gonzalez Magdalena, Connelly Margery A, Wood Alexis C, Tsai Michael Y, Taylor Kent D, Rich Stephen S, Rotter Jerome I, Otvos James D, Bentley Amy R, Mora Samia, Aschard Hugues, Rao D C, Gu Charles, Chasman Daniel I, Manning Alisa K
Abstract excerpt
Large-scale gene-environment interaction (GxE) discovery efforts often involve analytical compromises for the sake of data harmonization and statistical power. Refinement of exposures, covariates, outcomes, and population subsets may be helpful to establish often-elusive replication and evaluate potential clinical utility. Here, we used additional datasets, an expanded set of statistical models, and interrogation...
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