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Article

T-cell activation and HLA-regulated response to smoking in the deep airways of patients with multiple sclerosis.

Clinical immunology (Orlando, Fla.) - 1 Aug 2016

Öckinger Johan, Hagemann-Jensen Michael, Kullberg Susanna, Engvall Benita, Eklund Anders, Grunewald Johan, Piehl Fredrik, Olsson Tomas, Wahlström Jan

Abstract excerpt

Cigarette smoking is a risk factor for multiple sclerosis (MS), and the risk is further multiplied for HLA-DRB1*15(+) smokers. To define the smoke-induced immune responses in the lung we performed bronchoscopy with bronchoalveolar lavage (BAL) on smokers and non-smokers, both MS-patients and healthy volunteers. In the BAL, non-smokers with MS showed an increased preformed CD40L expression in CD4(+) T-cells while...

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PMID: 27339331
DOI: 10.1016/j.clim.2016.06.006

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