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Article

Triaminopyrimidine is a fast-killing and long-acting antimalarial clinical candidate

31 Mar 2015

Abstract excerpt

The widespread emergence of Plasmodium falciparum (Pf) strains resistant to frontline agents has fuelled the search for fast-acting agents with novel mechanism of action. Here, we report the discovery and optimization of novel antimalarial compounds, the triaminopyrimidines (TAPs), which emerged from a phenotypic screen against the blood stages of Pf. The clinical candidate (compound 12) is efficacious in a mouse...

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PMID: 25823686
DOI: 10.1038/ncomms7715

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