Article
Na(+) regulation in the malaria parasite Plasmodium falciparum involves the cation ATPase PfATP4 and is a target of the spiroindolone antimalarials.
Cell host & microbe - 13 Feb 2013
Spillman Natalie J, Allen Richard J W, McNamara Case W, Yeung Bryan K S, Winzeler Elizabeth A, Diagana Thierry T, Kirk Kiaran
Abstract excerpt
The malaria parasite Plasmodium falciparum establishes in the host erythrocyte plasma membrane new permeability pathways that mediate nutrient uptake into the infected cell. These pathways simultaneously allow Na(+) influx, causing [Na(+)] in the infected erythrocyte cytosol to increase to high levels. The intraerythrocytic parasite itself maintains a low cytosolic [Na(+)] via unknown mechanisms. Here we present...
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