Article
Spiroindolones, a potent compound class for the treatment of malaria.
Science (New York, N.Y.) - 3 Sept 2010
Rottmann Matthias, McNamara Case, Yeung Bryan K S, Lee Marcus C S, Zou Bin, Russell Bruce, Seitz Patrick, Plouffe David M, Dharia Neekesh V, Tan Jocelyn, Cohen Steven B, Spencer Kathryn R, González-Páez Gonzalo E, Lakshminarayana Suresh B, Goh Anne, Suwanarusk Rossarin, Jegla Timothy, Schmitt Esther K, Beck Hans-Peter, Brun Reto, Nosten Francois, Renia Laurent, Dartois Veronique, Keller Thomas H, Fidock David A, Winzeler Elizabeth A, Diagana Thierry T
Abstract excerpt
Recent reports of increased tolerance to artemisinin derivatives--the most recently adopted class of antimalarials--have prompted a need for new treatments. The spirotetrahydro-beta-carbolines, or spiroindolones, are potent drugs that kill the blood stages of Plasmodium falciparum and Plasmodium vivax clinical isolates at low nanomolar concentration. Spiroindolones rapidly inhibit protein synthesis in P....
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.