Article
5-azacytidine inhibits nonsense-mediated decay in a MYC-dependent fashion.
EMBO molecular medicine - 1 Dec 2014
Bhuvanagiri Madhuri, Lewis Joe, Putzker Kerstin, Becker Jonas P, Leicht Stefan, Krijgsveld Jeroen, Batra Richa, Turnwald Brad, Jovanovic Bogdan, Hauer Christian, Sieber Jana, Hentze Matthias W, Kulozik Andreas E
Abstract excerpt
Nonsense-mediated RNA decay (NMD) is an RNA-based quality control mechanism that eliminates transcripts bearing premature translation termination codons (PTC). Approximately, one-third of all inherited disorders and some forms of cancer are caused by nonsense or frame shift mutations that introduce PTCs, and NMD can modulate the clinical phenotype of these diseases. 5-azacytidine is an analogue of the naturally...
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