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Article

Metastatic tumor evolution and organoid modeling implicate TGFBR2 as a cancer driver in diffuse gastric cancer.

Genome biology - 27 Aug 2014

Nadauld Lincoln D, Garcia Sarah, Natsoulis Georges, Bell John M, Miotke Laura, Hopmans Erik S, Xu Hua, Pai Reetesh K, Palm Curt, Regan John F, Chen Hao, Flaherty Patrick, Ootani Akifumi, Zhang Nancy R, Ford James M, Kuo Calvin J, Ji Hanlee P

Abstract excerpt

BACKGROUND: Gastric cancer is the second-leading cause of global cancer deaths, with metastatic disease representing the primary cause of mortality. To identify candidate drivers involved in oncogenesis and tumor evolution, we conduct an extensive genome sequencing analysis of metastatic progression in a diffuse gastric cancer. This involves a comparison between a primary tumor from a hereditary diffuse gastric...

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Source

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Identifiers

PMID: 25315765
DOI: 10.1186/s13059-014-0428-9
PMCID: PMC4145231

Genes

TGFBR2
FGFR2
CDH1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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