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Article

Human gastric cancer modelling using organoids.

Gut - 1 Feb 2019

Seidlitz Therese, Merker Sebastian R, Rothe Alexander, Zakrzewski Falk, von Neubeck Cläre, Grützmann Konrad, Sommer Ulrich, Schweitzer Christine, Schölch Sebastian, Uhlemann Heike, Gaebler Anne-Marlene, Werner Kristin, Krause Mechthild, Baretton Gustavo B, Welsch Thilo, Koo Bon-Kyoung, Aust Daniela E, Klink Barbara, Weitz Jürgen, Stange Daniel E

Abstract excerpt

OBJECTIVE: Gastric cancer is the second leading cause of cancer-related deaths and the fifth most common malignancy worldwide. In this study, human and mouse gastric cancer organoids were generated to model the disease and perform drug testing to delineate treatment strategies. DESIGN: Human gastric cancer organoid cultures were established, samples classified according to their molecular profile and their...

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Identifiers

PMID: 29703791
DOI: 10.1136/gutjnl-2017-314549
PMCID: PMC6352409

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Source receipt: pubmed, retrieved 7 Sept 2026.

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