Article
Modelling hereditary diffuse gastric cancer initiation using transgenic mouse-derived gastric organoids and single-cell sequencing.
The Journal of pathology - 1 Jul 2021
Dixon Katherine, Brew Tom, Farnell David, Godwin Tanis D, Cheung Simon, Chow Christine, Ta Monica, Ho Germain, Bui Minh, Douglas J Maxwell, Campbell Kieran R, El-Naggar Amal, Kaurah Pardeep, Kalloger Steve E, Lim Howard J, Schaeffer David F, Cochrane Dawn, Guilford Parry, Huntsman David G
Abstract excerpt
Hereditary diffuse gastric cancer (HDGC) is a cancer syndrome caused by germline variants in CDH1, the gene encoding the cell-cell adhesion molecule E-cadherin. Loss of E-cadherin in cancer is associated with cellular dedifferentiation and poor prognosis, but the mechanisms through which CDH1 los...
Topics
- Animals
- Cadherins
- Cell Transformation, Neoplastic
- Disease Models, Animal
- Gene Expression Regulation, Neoplastic
- Genetic Predisposition to Disease
- Mice
- Mice, Transgenic
- Organoids