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Article

Somatic mouse models of gastric cancer reveal genotype-specific features of metastatic disease.

Nature cancer - 1 Feb 2024

Leibold Josef, Tsanov Kaloyan M, Amor Corina, Ho Yu-Jui, Sánchez-Rivera Francisco J, Feucht Judith, Baslan Timour, Chen Hsuan-An, Tian Sha, Simon Janelle, Wuest Alexandra, Wilkinson John E, Lowe Scott W

Abstract excerpt

Metastatic gastric carcinoma is a highly lethal cancer that responds poorly to conventional and molecularly targeted therapies. Despite its clinical relevance, the mechanisms underlying the behavior and therapeutic response of this disease are poorly understood owing, in part, to a paucity of tractable models. Here we developed methods to somatically introduce different oncogenic lesions directly into the murine...

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Identifiers

PMID: 38177458
DOI: 10.1038/s43018-023-00686-w
PMCID: PMC10899107

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