Article
Divergent Routes toward Wnt and R-spondin Niche Independency during Human Gastric Carcinogenesis.
Cell - 9 Aug 2018
Nanki Kosaku, Toshimitsu Kohta, Takano Ai, Fujii Masayuki, Shimokawa Mariko, Ohta Yuki, Matano Mami, Seino Takashi, Nishikori Shingo, Ishikawa Keiko, Kawasaki Kenta, Togasaki Kazuhiro, Takahashi Sirirat, Sukawa Yasutaka, Ishida Hiroki, Sugimoto Shinya, Kawakubo Hirofumi, Kim Jihoon, Kitagawa Yuko, Sekine Shigeki, Koo Bon-Kyoung, Kanai Takanori, Sato Toshiro
Abstract excerpt
Recent sequencing analyses have shed light on heterogeneous patterns of genomic aberrations in human gastric cancers (GCs). To explore how individual genetic events translate into cancer phenotypes, we established a biological library consisting of genetically engineered gastric organoids carrying various GC mutations and 37 patient-derived organoid lines, including rare genomically stable GCs. Phenotype analyses...
Topics
- Adenocarcinoma
- Animals
- Antigens, CD
- Apoptosis
- Biomarkers, Tumor
- Cadherins
- Carcinogenesis
- Cell Proliferation
- Clustered Regularly Interspaced Short Palindromic Repeats