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Article

Rnf8 deficiency impairs class switch recombination, spermatogenesis, and genomic integrity and predisposes for cancer.

The Journal of experimental medicine - 10 May 2010

Li Li, Halaby Marie-Jo, Hakem Anne, Cardoso Renato, El Ghamrasni Samah, Harding Shane, Chan Norman, Bristow Robert, Sanchez Otto, Durocher Daniel, Hakem Razqallah

Abstract excerpt

Signaling and repair of DNA double-strand breaks (DSBs) are critical for preventing immunodeficiency and cancer. These DNA breaks result from exogenous and endogenous DNA insults but are also programmed to occur during physiological processes such as meiosis and immunoglobulin heavy chain (IgH) class switch recombination (CSR). Recent studies reported that the E3 ligase RNF8 plays important roles in propagating...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 20385750
DOI: 10.1084/jem.20092437
PMCID: PMC2867283

Genes

BRCA1
RNF8

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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