Article
Lsh/HELLS is required for B lymphocyte development and immunoglobulin class switch recombination.
Proceedings of the National Academy of Sciences of the United States of America - 18 Aug 2020
He Yafeng, Ren Jianke, Xu Xiaoping, Ni Kai, Schwader Andrew, Finney Richard, Wang Can, Sun Lei, Klarmann Kimberly, Keller Jonathan, Tubbs Anthony, Nussenzweig Andre, Muegge Kathrin
Abstract excerpt
Mutation of HELLS (Helicase, Lymphoid-Specific)/Lsh in human DNA causes a severe immunodeficiency syndrome, but the nature of the defect remains unknown. We assessed here the role of Lsh in hematopoiesis using conditional Lsh knockout mice with expression of Mx1 or Vav Cre-recombinase. Bone marrow transplantation studies revealed that Lsh depletion in hematopoietic stem cells severely reduced B cell numbers and...
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