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Article

Cdk12 is essential for embryonic development and the maintenance of genomic stability.

Cell death and differentiation - 1 Jun 2016

Juan H-C, Lin Y, Chen H-R, Fann M-J

Abstract excerpt

The maintenance of genomic integrity during early embryonic development is important in order to ensure the proper development of the embryo. Studies from cultured cells have demonstrated that cyclin-dependent kinase 12 (Cdk12) is a multifunctional protein that maintains genomic stability and the pluripotency of embryonic stem cells. Perturbation of its functions is also known to be associated with pathogenesis...

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Identifiers

PMID: 26658019
DOI: 10.1038/cdd.2015.157
PMCID: PMC4987723

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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