Article
Confirmation of childhood acute lymphoblastic leukemia variants, ARID5B and IKZF1, and interaction with parental environmental exposures.
PloS one - 1 Jan 2014
Evans Tiffany-Jane, Milne Elizabeth, Anderson Denise, de Klerk Nicholas H, Jamieson Sarra E, Talseth-Palmer Bente A, Bowden Nikola A, Holliday Elizabeth G, Rudant Jérémie, Orsi Laurent, Richardson Ebony, Lavis Laura, Catchpoole Daniel, Attia John R, Armstrong Bruce K, Clavel Jacqueline, Scott Rodney J
Abstract excerpt
Genome wide association studies (GWAS) have established association of ARID5B and IKZF1 variants with childhood acute lymphoblastic leukemia (ALL). Epidemiological studies suggest that environmental factors alone appear to make a relatively minor contribution to disease risk. The polygenic nature of childhood ALL predisposition together with the timing of environmental triggers may hold vital clues for disease...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.