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Article

A causal mechanism for childhood acute lymphoblastic leukaemia.

Nature reviews. Cancer - 1 Aug 2018

Greaves Mel

Abstract excerpt

In this Review, I present evidence supporting a multifactorial causation of childhood acute lymphoblastic leukaemia (ALL), a major subtype of paediatric cancer. ALL evolves in two discrete steps. First, in utero initiation by fusion gene formation or hyperdiploidy generates a covert, pre-leukaemic clone. Second, in a small fraction of these cases, the postnatal acquisition of secondary genetic changes (primarily...

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Source

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Identifiers

PMID: 29784935
DOI: 10.1038/s41568-018-0015-6
PMCID: PMC6986894

Genes

ETV6
RUNX1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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