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Article

ARID5B, IKZF1 and non-genetic factors in the etiology of childhood acute lymphoblastic leukemia: the ESCALE study.

PloS one - 1 Jan 2015

Rudant Jérémie, Orsi Laurent, Bonaventure Audrey, Goujon-Bellec Stéphanie, Baruchel André, Petit Arnaud, Bertrand Yves, Nelken Brigitte, Pasquet Marlène, Michel Gérard, Saumet Laure, Chastagner Pascal, Ducassou Stéphane, Réguerre Yves, Hémon Denis, Clavel Jacqueline

Abstract excerpt

Genome-wide association studies (GWAS) have identified that frequent polymorphisms in ARID5B and IKZF1, two genes involved in lymphoid differentiation, increase the risk of childhood acute lymphoblastic leukemia (ALL). These findings markedly modified the current field of research on the etiology of ALL. In this new context, the present exploratory study investigated the possible interactions between these...

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PMID: 25806972
DOI: 10.1371/journal.pone.0121348
PMCID: PMC4373901

Genes

IKZF1

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