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Article

Cross-talking noncoding RNAs contribute to cell-specific neurodegeneration in SCA7.

Nature structural & molecular biology - 1 Nov 2014

Tan Jennifer Y, Vance Keith W, Varela Miguel A, Sirey Tamara, Watson Lauren M, Curtis Helen J, Marinello Martina, Alves Sandro, Steinkraus Bruno, Cooper Sarah, Nesterova Tatyana, Brockdorff Neil, Fulga Tudor, Brice Alexis, Sittler Annie, Oliver Peter L, Wood Matthew J, Ponting Chris P, Marques Ana C

Abstract excerpt

What causes the tissue-specific pathology of diseases resulting from mutations in housekeeping genes? Specifically, in spinocerebellar ataxia type 7 (SCA7), a neurodegenerative disorder caused by a CAG-repeat expansion in ATXN7 (which encodes an essential component of the mammalian transcription coactivation complex, STAGA), the factors underlying the characteristic progressive cerebellar and retinal degeneration...

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Identifiers

PMID: 25306109
DOI: 10.1038/nsmb.2902
PMCID: PMC4255225

Genes

ATXN7

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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