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Article

UTteR control through miRs: fine-tuning ATXN1 levels to prevent ataxia.

Genes & development - 1 Sept 2020

Xie Mingyi, Swanson Maurice S

Abstract excerpt

Pathomechanistic studies of neurodegenerative diseases have documented the toxic effects of mutant protein expression, misfolding, and aggregation. However, alterations in the expression of the corresponding wild-type (WT) gene, due to either variations in copy number or transcriptional regulation, have also been linked to Alzheimer's and Parkinson's diseases. Another striking example of this mutant and WT...

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Identifiers

PMID: 32873576
DOI: 10.1101/gad.343020.120
PMCID: PMC7462066

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