Article

A human Staufen1 BAC transgenic mouse exhibits abnormal autophagy and neurodegeneration across the central nervous system

2025-09-23

Abstract excerpt

<title>Abstract</title> RNA-binding proteins (RBPs) play an essential role in development, normal functioning and human disease. Staufen1 (STAU1) is an RBP that regulates mRNA degradation and subcellular localization, and is part of the ATXN2 protein complex. Previously, we showed that STAU1 is overabundant in patient fibroblasts and in mouse models of Alzheimer’s disease (AD), amyotrophic lateral sclerosis...

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Literature Corpus work: e24c5f76-b26f-5f91-832f-1370f2f58383
DOI: 10.21203/rs.3.rs-7411941/v1

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