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hnRNPA1 orchestrates multi-layered regulation of SNCA expression

2025-04-03

Abstract excerpt

<title>Abstract</title> <p>Abnormal accumulation of alpha-synuclein (SNCA) is a hallmark of Parkinson’s disease (PD), yet the molecular mechanisms governing SNCA expression remain incompletely understood. The SNCA 3' untranslated region (3'UTR) plays a critical regulatory role, with linkage disequilibrium suggesting its involvement in sporadic PD. Analysis of SNCA 3'UTR isoforms revealed that longer variants exhi...

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Literature Corpus work: 0b99ab6c-ee78-535f-a209-1d1084d63516
DOI: 10.21203/rs.3.rs-6294566/v1

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