Article

Progressive degeneration in a new <i>Drosophila</i> model of Spinocerebellar Ataxia type 7

2023-11-11

Abstract excerpt

Spinocerebellar ataxia type 7 (SCA7) is a progressive neurodegenerative disorder resulting from abnormal expansion of polyglutamine (polyQ) in its disease protein, ataxin-7 (ATXN7). ATXN7 is part of Spt-Ada-Gcn5 acetyltransferase (SAGA), an evolutionarily conserved transcriptional coactivation complex with critical roles in chromatin remodeling, cell signaling, neurodifferentiation, mitochondrial health and autoph...

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Literature Corpus work: a6609395-0948-5ef3-a425-f3c83caae51e
DOI: 10.1101/2023.11.07.566106

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