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Control of HIV-1 in Elite Suppressors despite Ongoing Replication and Evolution in Plasma Virus

6 May 2010

Abstract excerpt

A subset of HIV-1-infected patients known as elite controllers or suppressors (ES) control the virus naturally. We have previously demonstrated sequence discordance between proviral and plasma gag clones in ES, much of which can be attributed to selective pressure from the host (J. R. Bailey, T. M. Williams, R. F. Siliciano, and J. N. Blankson, J. Exp. Med. 203:1357-1369, 2006). However, it is not clear whether...

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PMID: 20444904
DOI: 10.1128/jvi.00548-10

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