Article
Whole-genome resequencing of Escherichia coli K-12 MG1655 undergoing short-term laboratory evolution in lactate minimal media reveals flexible selection of adaptive mutations.
Genome biology - 1 Jan 2009
Conrad Tom M, Joyce Andrew R, Applebee M Kenyon, Barrett Christian L, Xie Bin, Gao Yuan, Palsson Bernhard Ø
Abstract excerpt
BACKGROUND: Short-term laboratory evolution of bacteria followed by genomic sequencing provides insight into the mechanism of adaptive evolution, such as the number of mutations needed for adaptation, genotype-phenotype relationships, and the reproducibility of adaptive outcomes. RESULTS: In the present study, we describe the genome sequencing of 11 endpoints of Escherichia coli that underwent 60-day laboratory...
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