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Article

BRG1 overexpression in smooth muscle cells promotes the development of thoracic aortic dissection.

BMC cardiovascular disorders - 11 Oct 2014

Yuan Yang, Wang Chong, Xu Jibin, Tao Jin, Xu Zhiyun, Huang Shengdong

Abstract excerpt

BACKGROUND: Here we investigated Brahma-related gene 1 (BRG1) expression in aortic smooth muscle cells (SMCs) and its role in the regulation of the pathological changes in aortic SMCs of thoracic arotic dissection (TAD). METHODS: BRG1, matrix metalloproteinase 2 (MMP2), and MMP9 mRNA and protein expression in human aortic specimens were examined by qPCR and western blot, respectively. The percentage of apoptotic...

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Share to Aorta, Thoracic
Share to Aortic Aneurysm, Thoracic

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Aortic Dissection

Share to Dilatation, Pathologic

Share to Matrix Metalloproteinase 2

Share to Matrix Metalloproteinase 9

Share to Myocytes, Smooth Muscle

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Source

Open in PubMed Open full text

Identifiers

PMID: 25304030
DOI: 10.1186/1471-2261-14-144
PMCID: PMC4531522

Genes

MMP2
MMP9

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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