Article
BMAL1 insufficiency increases the risk of thoracic aortic aneurysm and dissection.
Cardiovascular research - 24 Feb 2026
Song Wenyu, Fu Guangguo, Li Qing, Huo Chunxiu, Xiao Liwan, Liu Meiqi, Zhang Xueting, Sun Huanhuan, Shen Kangjie, Shi Lijie, Ni Lingyan, Zhou Peiyi, Huang Liqi, Qin Lieyang, Lai Hao, Wang Chunsheng, Tang Yun-Chi, Chen Jinmiao, Chang Hung-Chun, Wei Lai
Abstract excerpt
AIMS: Vascular smooth muscle cell (VSMC) apoptosis plays a key role in the development of thoracic aortic aneurysm and dissection (TAAD), a lethal cardiovascular disease with high mortality rates but limited pharmacological therapy. BMAL1 dysregulation is associated with apoptosis. However, it remains elusive whether BMAL1 dysregulation may aggravate VSMC apoptosis to participate in the development of TAAD....
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