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Article

Using multivariable Mendelian randomization to disentangle the causal effects of lipid fractions.

PloS one - 1 Jan 2014

Burgess Stephen, Freitag Daniel F, Khan Hassan, Gorman Donal N, Thompson Simon G

Abstract excerpt

BACKGROUND: Previous Mendelian randomization studies have suggested that, while low-density lipoprotein cholesterol (LDL-c) and triglycerides are causally implicated in coronary artery disease (CAD) risk, high-density lipoprotein cholesterol (HDL-c) may not be, with causal effect estimates compatible with the null. PRINCIPAL FINDINGS: The causal effects of these three lipid fractions can be better identified...

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Source

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Identifiers

PMID: 25302496
DOI: 10.1371/journal.pone.0108891
PMCID: PMC4193746

Genes

CAD

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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