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Article

Multivariable Mendelian randomization: the use of pleiotropic genetic variants to estimate causal effects.

American journal of epidemiology - 15 Feb 2015

Burgess Stephen, Thompson Simon G

Abstract excerpt

A conventional Mendelian randomization analysis assesses the causal effect of a risk factor on an outcome by using genetic variants that are solely associated with the risk factor of interest as instrumental variables. However, in some cases, such as the case of triglyceride level as a risk factor for cardiovascular disease, it may be difficult to find a relevant genetic variant that is not also associated with...

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Identifiers

PMID: 25632051
DOI: 10.1093/aje/kwu283
PMCID: PMC4325677

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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