Article
Influence of IFNL3/4 polymorphisms on the incidence of cytomegalovirus infection after solid-organ transplantation.
The Journal of infectious diseases - 15 Mar 2015
Manuel Oriol, Wójtowicz Agnieszka, Bibert Stéphanie, Mueller Nicolas J, van Delden Christian, Hirsch Hans H, Steiger Juerg, Stern Martin, Egli Adrian, Garzoni Christian, Binet Isabelle, Weisser Maja, Berger Christoph, Cusini Alexia, Meylan Pascal, Pascual Manuel, Bochud Pierre-Yves
Abstract excerpt
BACKGROUND: Polymorphisms in IFNL3 and IFNL4, the genes encoding interferon λ3 and interferon λ4, respectively, have been associated with reduced hepatitis C virus clearance. We explored the role of such polymorphisms on the incidence of cytomegalovirus (CMV) infection in solid-organ transplant recipients. METHODS: White patients participating in the Swiss Transplant Cohort Study in 2008-2011 were included. A...
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